RESUME CHRISTA BOER. Prof.dr. Christa Boer. VU University Medical Center. Phone (work): +31 (0) Date of birth: November

RESUME CHRISTA BOER Name: Nationality: Employer: Department: Phone (work): E-mail: Date of birth:

Prof.dr. Christa Boer Dutch VU University Medical Center Anesthesiology +31 (0) 204443830 [email protected] November 2 1971

POSITIONS AND EDUCATION • • •

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2014-current: Professor of Anesthesiology; Research Perioperative Care 2014-current: Program director MSc Cardiovascular Research VUmc 2010-current: Associate Professor in Anesthesiology, Research Manager Perioperative Medicine VUmc (BROK and BKO certified) 2012-2014: Editor-in-chief Netherlands Journal of Anesthesiology 2007-2010: Assistant Professor in Anesthesiology, VUmc 2005-2007: Medical Advisor, Abbott International, Hoofddorp 2001-2005: Assistant Professor in Physiology & Anesthesiology, VUmc 1996-2001: PhD training Anesthesiology/Physiology VUmc. Promoters: prof.dr. N. Westerhof & prof.dr. J.J. de Lange. Co-promoters: dr. P. Sipkema & dr. G.J. Scheffer. ‘Pulmonary artery function and endotoxin. The dual role of nitric oxide’ 1990-1996: Master Biomedical Sciences, Leiden University, Leiden

ACADEMIC APPOINTMENTS • • •

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2015; Associated Editorial Board member British Journal of Anaesthesia 2015; Co-chair EACTS/EACTA joint effort Patient Blood Management Guideline. 2015; Chair Subcommittee Haemostasis & Transfusion; European Association of Cardiothoracic Anaesthesiologists. 2015: Member Subcommittee Anesthesia Technology, World Federation Of Societies of Anaesthesiologists Conference 2016 2014: Member Academic Board Netherlands Society of Anesthesiology 2014: Member Scientific Committtee ICaR-VU 2013-2015: Member Forum van Toekomst VUmc/AMC 2013-current: Member EACTA subcommittee Hemostasis & Transfusion 2013: Chair Symposium Committee ICaR-VU Anniversary. April 17 2013, Amsterdam, the Netherlands 2012-current: Chair national Anesthesiology Research Consortium (ARC) 2012-2014: Chair DenkTank ICaR-VU 2011-2015: Member Executive Committee of the European Brain Injury Consortium (EBIC) 2010-2015: Chair National Platform Perioperative Hemostasis 2010-2012: Member Local Organizing Committee EACTA 2009-2010: Member Scientific Committee Annual meeting ESCTAIC

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2008-2009: Organization 1st and 2nd Journal Highlights Symposium 2009-current: Chair Symposium ‘Goal-directed coagulation management’, May 8 2009, VUmc 2008-current: Member Human Subjects Committee VUmc 2007-current: Member Scientific Committee Netherlands Society of Anesthesiology 2003-current: Project leader Institute for Cardiovascular Research Vrije Universiteit (ICaR-VU) 2003-2005: Vice-chair Institutional Animal Care committee 2004-2014: Member organizing committee Scientific Symposium NVA

MEMBERSHIPS • • • •

Dutch Society for Microcirculation European Association of Cardiothoracic Anaesthesiologists European Society of Anaesthesiology Netherlands Society of Anesthesiologists

SPAN OF CONTROL • • • • •

Post-doctoral fellow Laboratory for Physiology Laboratory technician Laboratory for Physiology Data managers for clinical trials 12 PhD students Yearly 10 bachelor and master students, including honor program participants

TEACHING ACTIVITIES • • • • • • • • • • • • • • • •

2015: Member academic learning committee master programme medicine 2014: Vice course coordinator General Course Minor bachelor Medicine 2014: Lecturer Angers Vascular Summer School (July 3-5 2014, Angers, France) 2013: Best teacher KOW Heart & Vessels 2013: Teacher postmaster courses EpidM 2012: Basis Kwalificatie Onderwijs (BKO) 2012: Teacher C/D education Residents Anesthesiology 2012: Teacher Ned. Ver. Thoraxchirurgie resident course. Bloedmanagement 2011: Teacher Ned. Ver. Trombose Hemostase PhD course. Massive bleeding 2010-current: Teacher Scientific Focus Education VUmc (medical ethics, autonomic function) 2009-current: Course leader ‘Perioperative Medicine M2 VUmc-Compas 2009-current: Teacher Cardiovascular Research Master (ICaR-VU) 2009-current: Member Education Committee Anesthesiology VUmc 2008-current: Supervisor Honours Program students VUmc-Compas 2007-current: Supervisor scientific internship curriculum Medicine / Biomedical Science 2008-current: Teacher regional training Anesthesiology residents

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CO-PROMOTOR/PROMOTOR PHD THESES dr. R. Arthur Bouwman Volatile anesthetics and the heart. Mechanisms of sevoflurane-induced cardioprotection. VU, 20 September 2006; Summa Cum Laude Promoter: Prof.dr. J.J. de Lange. Co-promotores: Dr. C. Boer and dr. R.J.P. Musters dr. Bektaș Atasever The microcirculatory response during cardiac surgery. UvA, 24 April 2012 Promotores: Prof.dr. C. Ince, prof.dr. B. de Mol. Co-promotor: dr. C. Boer dr. G. Franschman Prehospital management strategies and secondary injury in traumatic brain injury VU, 19 June 2013 Promotor: Prof.dr. S.A. Loer. Co-promotores: dr. C. Boer, dr. S.M. Peerdeman dr. L.J.M. Geeraedts jr. Management of trauma patients with life-threatening hemorrhage VU, 27 September 2013 Promotor: Prof.dr. H.J. Bonjer. Co-promotor: dr. C. Boer dr. C.E. van den Brom Dietary modulation of the effects of sevoflurane on myocardial perfusion, function and ischemic injury in rats VU, 30 January 2014 Promotor: Prof.dr. S.A. Loer. Co-promotores: dr. C. Boer, dr. R.A. Bouwman dr. A.B.A. Vonk Improvements of blood management in open heart surgery VU, 6 February 2014 Promotor: Prof.dr. S.A. Loer. Co-promotores: dr. C. Boer, prof.dr. L. Eijsman dr. J.R.M. Schreinemakers Analysis of oxygen mask-induced soft tissue and nasal bone problems in F-16 pilots UU, 11 September 2014 Promotor: Prof.dr. M. Kon. Co-promotor: dr. C. Boer dr. C.S.E. Bulte Autonomic modulation of myocardial microvascular responses and blood flow during sevoflurane anesthesia VU, 17 December 2014 Promotor: Prof.dr. S.A. Loer. Co-promotores: dr. R.A. Bouwman, dr. C. Boer drs. S.W.M. Keet Assessment of cardiovascular autonomic function in the perioperative setting VU, 30 October 2015 Promotores: Prof.dr. C. Boer, Prof.dr. S.A. Loer PHD COMMITTEE Natascha Cuper Jan Fraesdorff Jaap Dronkers Markus Lancé

January 2016

Utrecht University. Promotor: prof.dr. R. Verdaasdonk University of Amsterdam. Promotores: prof.dr. W. Schlack, prof.dr. M. Hollmann VU University. Promotor: prof.dr. M. Hopman-Rock Maastricht University. Promotor: prof.dr. M. Marcus

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University of Amsterdam. Promotores: prof.dr. W. Schlack, prof.dr. M. Hollmann Frances Wulfert University of Groningen. Promotores: prof.dr. G. Molema, prof.dr. J.G. Zijlstra, prof.dr. M.R.F. Struijs Jaap Jan Vos University of Groningen. Promotores: prof.dr. T.W.L. Scheeren Sabrine Hemmes University of Amsterdam. Promotores: prof.dr. M. Schulz, prof.dr. M. Hollmann Stefan Dieleman Utrecht University. Promotores: prof.dr. C.J. Kalkman, prof.dr. D. van Dijk Ranran Li University of Groningen. Promotores: prof.dr. G. Molema, prof.dr. J.A.A.M. Kamp J. Wietze Vermeijden University of Groningen. Promotores: prof.dr. T.W.L. Scheeren REVIEWER • • • • • • • • •

British Journal of Anaesthesiology (regular) Minerva Anestesiologica (regular) Journal of Cardiothoracic and Vascular Anesthesia European Journal of Pharmacology European Journal of Anaesthesiology Vox Sanguinis Grant proposals ZonMw, NHS British NIAA grants YIG grants NVA

INTERNATIONAL COLLABORATIONS • • •

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2015-current: Collaboration dr. Patrick Mayr, Technischen Universität München (TAVI) 2014-current: Collaboration prof.dr. Dan Dumont, Sunnybrook Institute Toronto (Ang1/Tie2) 2013-current: Collaboration prof.dr. Oz Shapira, Department of Cardiothoracic Surgery at Hadassah University hospital in Ein-Karem, Jerusalem, Israel 2012-current: Collaboration prof.dr. Hasan B. Alam. University of Michigan, Department of Surgery (TBI research) 2012-current: Collaboration prof.dr. Andrew Maas, Antwerpen, Belgium (TBI research) 2010-current: Collaboration dr. A. Koch and prof.dr. K. Zacharowski, Klinikum und Fachbereich Medizin, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany 2009-current: Collaboration prof.dr. C. Baufreton, Université d'Angers, Angers, France 2000: Post-doc in dept. of Physiology, Ludwig-Maximilians-Universität Munich, Germany 2002: Post-doc in dept. of Endocrinology, University of California, San Diego (UCSD), USA

NATIONAL MULTICENTER TRIAL PARTICIPATION •

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TRACE study (initiator and principle investigator, SEENEZ project (ZonMw); Routine posTsuRgical Anesthesia visit to improve patient outcome) REPULS study (initiator; REnal function after PULSatile flow during cardiopulmonary bypass in cardiac surgery) OPERA study (initiator and principle investigator; Outcome of PERioperative Analgesia) COGUIDE study (initiator and principle investigator)

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DECS study (participant; Dexamethason in cardiac surgery; NCT00293592; Prof.dr. D. van Dijk)

INTERNATIONAL MULTICENTER TRIAL PARTICIPATION • • • •

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PROBESE (participant; RCT obese patients; ESA trial network) GIFT study (participant; Goal dIrected perFusion Trial; Prof.dr. M. Ranucchi) ISOS study (participant; International Surgical Outcomes Study; Prof.dr. R.M. Pearse)) POPULAR study (participant, ESA CTN; POstAnaesthesia PULmonary complications After use of muscle Relaxants in Europe: a Prospective Observational International Multi–center Cohort Study; NCT01865513; Prof.dr. M. Blobner) CENTER-TBI FP7 program (principle investigator; Prof.dr. A. Maas) LAS VEGAS study (participant, ESA CTN; Local Assessment of Ventilatory Management During General Anesthesia for Surgery and effects on Postoperative Pulmonary Complications: a Prospective Observational International Multi–center Cohort Study; NCT 01601223; Prof.dr. M. Schultz)

INVITED LECTURES •

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Stolling en inflammatie: from bench to bedside. Christmas stollingssymposium. December 18 2015, AMC Amsterdam, the Netherlands. INVOS brain monitoring in cardiac arrest. Brainstorming Cardiac Surgery. December 9-10 2015, Kerkrade, the Netherlands. Transfusion: Plasma. Maastricht Perioperative Bleeding Management. September 6-11 2015. Vaals, the Netherlands. What does blood transfusion to the microcirculation? Faculty EACTA-ICCVA 2015 meeting. June 24-26 2015, Goteborg, Sweden. Cerebral tissue oxygenation measurements in patients with cardiopulmonary arrest. Masterclass Brain Monitoring. June 11-12 2015, Groningen, the Netherlands. Surgical stress: consequences for heparin management and hemostasis. Options and Outcome Meeting. May 28 – June 1 2015, Rome, Italy The microcirculation: overview in a clinical context. INTERCEPT meeting. April 9-11 2015, Milano, Italy FFP: wat is de plek? Christmas stollingssymposium. December 19 2014, AMC Amsterdam, the Netherlands. All about fibrinolysis in haemorrhagic shock. Innsbruck Winter Symposium for Coagulation. December 11-12 2014, Innsbruck, Austria Key note speaker ANZCP conference. November 6-8 2014. Auckland, New Zeeland. Around the clot. Faculty EACTA-ICCVA 2014 meeting. September 17-19 2014, Florence, Italy Pathophysiology of the microcirculation. Faculty MiECT meeting. June 13-14 2014, Thessaloniki, Greece Surgical stress: consequences for heparin management and hemostasis. Options and Outcome Meeting. May 15-17 2014, Rome, Italy Clinical benefits of individualized heparin and protamine management in cardiac surgery. SWESECT meeting. January 31 2014, Vadstena, Sweden Medical Ethics in daily practice. Topics in IC. December 12, 2013, Netherlands Individualised heparin and protamin management in cardiac surgery. Symposium for cardiopulmonary bypass. November 30 2013, Basel, Switzerland

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Expanding patient benefits of intraoperative hemodynamic monitoring using a non-invasive approach. IFAD congress. November 29-30 2013, Antwerpen, Belgium Challenging microcirculation in cardiac surgery. INTERcept meeting. April 18-20 2013, Milano, Italy Perioperative hemodynamic goal-directed therapy. ISICEM congress. March 19-22 2013, Brussels, Belgium Perioperatieve Hemostase: Stolling & Antistolling. Organizing committee and lecturer. March 14 2013, Amsterdam, the Netherlands Surgical stress: consequences for heparin management and hemostasis. Outcome and Options Meeting. March 7-8 2013, Rome, Italy Anticoagulation in cardiac surgery: looking for the right balance. International congress Transparency in Transfusion Medicine. February 1-2 2013, Zwolle, the Netherlands Perioperatieve hemostase: nieuwe ontwikkelingen en uitdagingen. Sanquin evening. January 23 2013, Amsterdam, the Netherlands Stollingssympoisum AMC. Organizing committee and lecturer. December 14 2012; December 13 2013, Amsterdam, the Netherlands Point-of-Care conference. December 13 2012, Utrecht, the Netherlands Chair and lecturer super-user workshop ROTEM. November 23 2012, Mijdrecht, the Netherlands Perioperatieve hemostase. Symposium Bloedstollend AMC. July 3 2012, Amsterdam, the Netherlands The benefits of tailor-made heparin and protamine management for perioperative hemostasis. Expert meeting. May 18 2012, Hannover, Germany Visualisatie van hemostaseveranderingen. April 11 2012, Breda, the Netherlands Perioperatieve hemostase: stolling als vitale functie. Symposium Bloedstollend Zaandam. November 30 2011, Zaandam, the Netherlands Stolling en vulling bij de traumapatiënt. Spoedsymposium SIGRA. November 24 2011, Amsterdam, the Netherlands Hemostase & stolling. Refereeravond JBZ. November 1 2011, Den Bosch, the Netherlands The benefits of tailor-made heparin and protamine management for perioperative hemostasis. Outcome & Options meeting 2011. October 28 2011, Rome, Italy. Nexfin. Totally non-invasive cardiac output. Eur. Soc. Anaesth, June 11-14 2011, Amsterdam Innovative approaches in anesthesia research. Eur. Soc. Anaesth, June 11-14 2011, Amsterdam Chair and lecturer International Nexfin workshop. April 18-19 2011, VUmc, Amsterdam, the Netherlands Bleeding in perioperative medicine. International symposium on bleeding 2010. Maastricht, the Netherlands Nexfin HD: Clinical Experience. ESCTAIC 2010, Amsterdam, the Netherlands Which Experiment for which Question. ESA 2008, Copenhagen, Denmark The mechanism of sevoflurane-induced cardioprotection. ASA, 2003, San Francisco, USA NO measurements in isolated arteries: fact or fiction? Eur Soc Microcirculation, 2002, Exeter, UK

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In vitro endothelial cell barrier disruption after exposure to plasma from patients subjected to cardiopulmonary bypass. EACTA-ICCVA 2014 meeting, September 17-19 2014, Florence, Italy

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Patient determinants for protamine overdosing in cardiac surgery. FECECT meeting, June 1215 2013, Toledo, Spain Individualized heparin and protamine management reduces the clotting time after cardiopulmonary bypass and blood loss in valve surgery. FECECT meeting, June 12-15 2013, Toledo, Spain Chair and lecturer symposium FFP use. June 28 2011, VUmc, Amsterdam, the Netherlands Caput. Department of Anesthesiology, UMCG, 2009, Groningen Recent developments in cardiovascular anesthesiology. 2e JH Symposium, 2009, Amsterdam Recent developments in neuroanesthesiology. 1st JH Symposium, 2008, Amsterdam Septal thickness in RV overload. American Society of Anesthesiology, 2007. San Francisco, USA Diabetic cardiomyopathy. Heart Failure Association 2005, Lissabon, Portugal High-fat diet induced cardiac dysfunction in rats. Endo-Neuro-Psycho meeting, 2004, Utrecht Pulmonary artery function and nitric oxide. NVIC 2002, Amsterdam LPS reduces sensitivity to NO in pulmonary arteries. Benelux Soc Microcirc 2000, Amsterdam

AWARDS RESEARCH GROUP •

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2015: Third price Young Investigator Award. M. Trieu. Dutch-German Microcirculation Meeting 2015, September 22-24 2015, Hannover, Germany. 2014: Second price best oral. EACTA-ICCVA 2014 meeting, September 17-19 2014, Florence, Italy 2013: Best presentation HP symposium. A. Duvekot 2013: Best Poster Award. ISCB, September 2013, Copenhagen, Denmark. A. Duvekot 2012: NVA Best oral presentation. N.J. Koning 2010: StudentenOnderzoeksPrijs 2010. N.J. Koning 2009: Scientific Award. TraumaCare 2009, Ulm 2009: Award outstanding abstract. Euroburn 2009, Lausanne 2009: Best Scientific presentation NVA annual conference. (M. van der Horst) 2008: 2nd price abstract competition. VUmc Scientific day 2002: Nitric Oxide Research price. ESM, Exeter, UK

RESEARCH GRANTS • • •

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2015; ICaR-VU grant Hyperspectral Camera (€25,000; co-applicant) 2015: SEENEZ – ZonMw TRACE study (€ 288,608.00; projectleader) 2015: Innovation fund VUMC - Preoperatieve diagnostiek en behandeling van (pre)diabetes ter voorkoming van intraoperatieve complicaties ((€25,225; main applicant) 2015: Medtronic grant for FUSION study (prof.dr. O. Shapira; Jerusalem Israel; €175,000; Coapplicant 2015: Achmea grant for BRAIN-PROTECT (dr. P. Schober; €266,000; Co-applicant) 2014: ZonMw GGG Hyperoxie (prof.dr. Y. Smulders; €50,000; Co-applicant) 2014: Young Investigator Grant NVA (dr. M. van Meurs UMCG; €50,000; Co-applicant). 2014: Covidien Investigator Initiated Study NIRS. (€6,000; main applicant) 2013: Nexfin-TD study (€25,000; dr. C. Boer; participant) 2012: ICaR-VU grant Glycocheck (€15,000; Drs. A.B.A. Vonk, dr. M.C. de Waard, dr. C. Boer)

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2012: ZonMw Prevention Program (€435,000 + €35,000 matching; main applicant/project leader) 2011: ICaR-VU grant Chronolog (€15,000; Drs. A.B.A. Vonk, Dr. C. Boer) 2011: Fellow grant Dutch Brain Foundation (€150,000; Dr. P. Schober, Dr. C. Boer) 2011: Grant European Association of Cardiothoracic Anaesthesiologists (€12,500; Project leader) 2010: Start-up grant ICaR-VU (€44,000; Project leader). 2010: Clinical Fellow ZonMw (dr. R.A. Bouwman; €160,000; Scientific Supervisor). 2010: Young Investigator Grant NVA (dr. R.A. Bouwman; €50,000; Scientific Supervisor). 2009: Dekker Stipend – student edition (N.J. Koning; €3,000; Scientific Supervisor). 2009: LPT-grant Health Insurance Company. Zorgverzekeraars (€54,340; Applicant). 2009: ICaR-VU grant ROTEM and Nexfin (€30,000; Applicant). 2008: Brahms Prohormone study (€30,000; Project leader). 2008: Research Grant European Society of Anesthesiology (€15,000; Applicant). 2008: Dekker stipendium Netherlands Heart Foundation (€160,000; Project supervisor). 2005: ICaR-VU grant Millar pressure wire system (€53,000; Applicant). 2005: NWO Mozaiek grant (€220,000; Applicant). 2005: ICaR-VU PhD grant (grant 200375; €180,000; Collaborator). 2005: ZonMW AGIKO stipend dr. R.A. Bouwman (920-03-255; €62,000; Applicant). 2004: ICaR-VU grant echocardiography small animals (€80,000; Project leader). 2004: Research grant Netherlands Diabetes Society (2004.00.052; €251,000; Project leader). 2003: Research grant Netherlands Diabetes Society (2003.00.029; €256,000; Co-applicant). 2003: ICaR-VU PhD grant (€180,000; Co-applicant). 1999: NWO SIR Travel grant (SIR 15-2563; €3,000; Applicant).

CITATION ANALYSIS (31-12-2015) Hirsch index Number of citations

January 2016

18 1300

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PUBLICATIONS 2015 1. 2. 3.

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Koning NJ, Vonk AB, Vink H, Boer C. Side-by-side alterations in glycocalyx thickness and perfused microvascular density during acute microcirculatory alterations in cardiac surgery. Microcirculation 2015. Scharwächter WH, Keet SW, Stoecklein K, Loer SA, Boer C. Health risk factors in the anaesthesia population. J Clin Anesth 2015. Van den Brom CE, Boly C, Bulte CS, Van den Akker R, Kwekkeboom R, Loer SA, Boer C, Bouwman RA. Myocardial perfusion and function are distinctly altered by sevoflurane anesthesia in diet-induced prediabetic rats. J Diabet Res 2015. De Jong JR, Boer C. Calculating the protamine dose necessary to neutralize heparin in all patients under all circumstances. JCVA 2015. Koning NJ, Overmars MA, van den Brom CE, van Bezu J, Simon LE, Vonk AB, Girbes AR, van Nieuw Amerongen GP, Boer C. Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function. BJA 2015 Nicia SB, Van Veelen TA, Stens J, Koopman MM, Boer C. Detection of volume loss using Nexfin haemodynamic parameters in spontaneously breathing subjects. Anaesthesia 2015. Stens J, Oeben J, Van Dusseldorp AA, Boer C. Non-invasive measurements of pulse pressure variation and stroke volume variation in anesthetized patients using the Nexfin blood pressure monitor. J Clin Monitor Comput 2015. Teligui L, Dalmayrac E, Corbeau JJ, Bouquet E, Godon A, Denommé AS, Binuani P, Verron L, Boer C, Baufreton C. Ex vivo simulation of cardiopulmonary bypass with human blood for hemocompatibility testing. Perfusion 2015. Schreinemakers JR, Boer C, Van Amerongen PC, Kon M. Pressure effects on the nose by an in-flight oxygen mask during simulated flight conditions. J Royal Army Med Corps 2015.

2015 10.

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Van Osch D, Dieleman JM, Nathoe HM, Boasson MP, Kluin J, Bungel JJ, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, De Lange F, Boer C, Van Dijk D. For the Dexamethasone for Cardiac Surgery (DECS) study group. Intraoperative high-dose dexamethasone in cardiac surgery and the risk of postoperative bleeding related complications. Annals Thorac Surg 2015;100:2237–2242. Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, Kluin J, Waikar SS. for the Dexamethasone for Cardiac Surgery (DECS) Study Group Intraoperative High-Dose Dexamethasone and Severe AKI after Cardiac Surgery. JASN 2015;26;2947-2951. Bossers SM, Schwarte LA, Loer SA, Twisk JWR, Boer C, Schober P. Experience in Prehospital Endotracheal Intubation Significantly Influences Mortality of Patients with Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. PLoS ONE 2015;10:e0141034. Duvekot A, Viersen VA, Dekker SE, Geeraedts jr LM, Schwarte LA, Spoelstra-de Man AM, Van de Ven PM, Van den Brom CE, De Waard MC, Loer SA, Boer C. Low cerebral oxygenation levels during resuscitation in out-of-hospital cardiac arrest are associated with hyperfibrinolysis. Anesthesiology 2015;123:820-829. Meesters MI, Lancé MD, Van der Steeg R, Boer C. The value of the thromboelastometry heparinase assay (HEPTEM) in cardiac surgery. Thromb Haemost 2015;114:1058-1063. Meesters MI, Koch A, Kuiper G, Zacharowski K, Boer C. Instability of the non-activated rotational thromboelastometry assay (NATEM) in citrate stored blood. Thromb Res 2015;136:481-483. Hoefeijzers MP, Ter Horst LH, Koning NJ, Vonk AB, Boer C, Elbers PW. The pulsatile perfusion debate in cardiac surgery: answers from the microcirculation? J Cardiothor Vasc Anesth 2015;29:761-767. Lankhorst S, Keet SW, Bulte CS, Boer C. The impact of autonomic dysfunction on peri-operative cardiovascular complications. Anaesthesia 2015;70:336-343. Bulte CSE, Boer C, Loer SA. Perioperative myocardial perfusion: An anesthesiologists’ concern? Curr Op Anesth 2015;28:101-106. Van Osch D, Dieleman JM, van Dijk D, Jacob KA, Kluin J, Doevendans PA, Nathoe HM; DExamethasone for Cardiac Surgery (DECS) study group (Boer C)*; DExamethasone for Cardiac

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Surgery DECS study group. Dexamethasone for the prevention of postoperative atrial fibrillation. Int J Cardiol 2015;182C:431-437. Stens J, de Wolf SP, van der Zwan RJ, Koning NJ, Dekker NA, Hering JP, Boer C. Microcirculatory perfusion during different perioperative haemodynamic strategies. Microcirculation 2015;22:267-275.. Lier MA, Douwenga WM, Yilmaz F, Schats R, Hompes PGA, Boer C, Mijatovic V. Patient controlled remifentanil analgesia as alternative for pethidine with midazolam during oocyte retrieval in IVF/ICSI procedures: a randomized controlled trial. Pain Practice 2015;15:487-495.

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Vonk AB, Meesters MI, van Dijk WB, Eijsman L, Romijn JW, Jansen EK, Loer SA, Boer C. Ten-year patterns in blood product utilization during cardiothoracic surgery with cardiopulmonary bypass in a tertiary hospital. Transfusion 2014;54:2608-2616. Koning NJ, Atasever B, Vonk AB, Boer C. Changes in microcirculatory perfusion and oxygenation during cardiac surgery with or without cardiopulmonary bypass. J Cardiothor Vasc Anesth 2014;28:13311340. Koning NJ, Simon LE, Asfar P, Baufreton C, Boer C. Systemic microvascular shunting through hyperdynamic capillaries after acute physiological disturbances following cardiopulmonary bypass. Am J Physiol Heart Circ Physiol 2014;307:H967-75. Meesters MI, Boer C. Cessation of antithrombotic therapy before surgery: Weighing thrombosis and bleeding risks. Neth Heart J 2014;22:370-371. Dekker SE, Sillesen M, Bambakidis T, Guang Jin G, Liu B, Boer C, Johansson PI, Halaweish I, Maxwell J, Alam HB. Normal saline disrupts coagulation and endothelial function following Traumatic Brain Injury and hemorrhagic shock. Surgery 2014;56:556-63. Bunge JJ, van Osch D, Dieleman JM, Jacob KA, Kluin J, van Dijk D, Nathoe HM; Dexamethasone for Cardiac Surgery (DECS) Study Group (Boer C)*. Dexamethasone for the prevention of postpericardiotomy syndrome: A DExamethasone for Cardiac Surgery substudy. Am Heart J 2014;168:126-31. Ottens TH, Dieleman JM, Sauër AM, Peelen LM, Nierich AP, de Groot WJ, Nathoe HM, Buijsrogge MP, Kalkman CJ, van Dijk D; For the Dexamethasone for Cardiac Surgery (DECS) Study Group (Boer C)*. Effects of Dexamethasone on Cognitive Decline after Cardiac Surgery: A Randomized Clinical Trial. Anesthesiology 2014;121:492-500. Schreinemakers JRC, Boer C, Van Amerongen PCGM, Kon M. Exerted pressure by an in-flight oxygen mask. Aviat Space Environ Med 2014;85:745–9. De Vries HM, Dekker SE, Boer C. Interpreting lactate clearance to predict mortality in trauma. J Trauma Acute Care Surg 2014;77:183. Dekker SE, Viersen VA, Duvekot A, De Jong M, van den Brom CE, van de Ven PM, Schober P, Boer C. Lysis Onset Time as diagnostic rotational thromboelastometry parameter for fast detection of hyperfibrinolysis. Anesthesiology 2014;121:89-97. Dekker SE, Sillesen M, Bambakidis T, Andjielkovic AV, Jin G, Liu B, Boer C, Johansson PI, Linzel D, Halaweish I, Alam HB. Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock. J Surg Res 2014;190:312-8. Teligui L, Dalmayrac E, Mabilleau G, Macchi L, Godon A, Corbeau J-J, Bouquet E,1 Denommé A, Boer C, Baufreton C. An ex-vivo evaluation of blood coagulation and thromboresistance of two extracorporeal circuit coatings with low and full heparin dose. ICVTS 2014;18:763-9. De Man FR, Erwteman M, Van Groeningen D, Ziedses des Plantes PV, Boer C, Loer SA, Krage R. The effect of audible alarms on response times to adverse events in a simulated anaesthesia environment: a randomised trial. Anaesthesia 2014;69:598-603. Meesters MI, Vonk AB, Van de Weerdt EK, Kamminga SK, Boer C. Level of agreement between laboratory and point-of-care prothrombin time before and after cardiopulmonary bypass in cardiac surgery. Thromb Res 2014;133:1141-4. Keet SW, Bulte CS, Sivanathan A, Verhees L, Allaart CP, Boer C, Bouwman RA. Cardiovascular autonomic function testing under nonstandardised and standardised conditions in cardiovascular patients with type II diabetes mellitus. Anaesthesia 2014;69:476-83. Bulte CS, Van den Brom CE, Loer SA, Boer C, Bouwman RA. Myocardial blood flow under general anaesthesia with sevoflurane in type 2 diabetic patients: a pilot study. Cardiovasc Diab 2014;13:62.

January 2016

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39.

Vonk AB, Veerhoek D, Van den Brom CE, Van Barneveld LJ, Boer C. Individualized heparin and protamine management improves rotational thromboelastometric parameters and postoperative hemostasis in valve surgery. J Cardiothor Vasc Anesth 2014;28:235-241. Koning NJ, Vonk AB, Meesters MI, Oomens T, Verkaik M, Jansen EK, Baufreton C, Boer C. Microcirculatory perfusion is preserved during off-pump but not on-pump cardiac surgery. J Cardiothor Vasc Anesth 2014;28:336-41.

2013 40.

41.

42.

43. 44.

45. 46. 47. 48.

49.

50.

51.

52.

Vonk AB, Meesters MI, Garnier RP, Romijn JW, Van Barneveld LJ, Heymans MW, Jansen EK, Boer C. Intraoperative cell salvage is associated with reduced postoperative blood loss and transfusion requirements in cardiac surgery: a cohort study. Transfusion 2013;53:2782-2789. Boly CA, Reesink KD, Van den Tol P, Jansen EK, Westerhof BE, Boer C, Bouwman RA. Minimally invasive intraoperative estimation of left-ventricular end systolic elastance with phenylephrine as loading intervention. BJA 2013;111:750-758. Koch A, Meesters MI, Scheller B, Boer C, Zacharowski K. Systemic endotoxin activity correlates with clot formation: an observational study in patients with early systemic inflammation and sepsis. Critical Care 2013;17:R198. Bulte CS, Boer C, Loer SA, Bouwman RA. Perioperative assessment of myocardial microvascular responsiveness in patients. Anesth Analg 2013;117:746. Franschman G, Andriessen TM, Boer C, Van der Naalt J, Horn J, Haitsma I, Vos PE. Physician-based emergency medical service deployment characteristics in severe traumatic brain injury: a Dutch multicenter study. Injury 2013;44:1232-1236. De Man FR, Greuters S, Boer C, Veerman DP, Loer SA. Intraoperative monitoring – many alarms with minor impact. Anaesthesia 2013;68:804-810. Keet SW, Bulte CS, Garnier RP, Boer C, Bouwman RA. Short-term heart rate variability in healthy adults. Anaesthesia 2013;68:775-777. Koning NJ, Boer C. Reply to Pancheva, Panchev, and Pancheva. J Appl Physiol 2013;114:1759. Van den Brom CE, Bulte CS, Loer SA, Bouwman RA, Boer, C. Diabetes, perioperative ischaemia and volatile anaesthetics: Consequences of derangements in myocardial substrate metabolism. Cardiovas Diabetol 2013;12:42. Van Lammeren A, Dols A, Van de Ven PM, Greuters S, Boer C, Loer SA, Stek M. Etomidate and seizure duration in electroconvulsive therapy: is there a dose-dependent relation? J ECT 2013;29:101105. Bulte CS, Slikkerveer J, Kamp O, Heymans MW, Loer SA, De Marchi SF, Vogel R, Boer C, Bouwman RA. General anesthesia with sevoflurane decreases myocardial blood volume and flow reserve in healthy humans. Anesth Analg 2013;116:767-774. Giannakopoulos GF, Kolodzinskyi MN, Christiaans HMT, Boer C, de Lange-de Klerk ESM, Zuidema WP, Bloemers FW, Bakker FC. Effect of Helicopter Emergency Medical Services (HEMS) care in a cohort of 1,073 polytraumatized patients. Eur J Emerg Med 2013;20:79-85. Bossers SM, de Boer RD, Boer C, Peerdeman SM. The diagnostic accuracy of brain microdialysis during surgery: a qualitative systematic review. Acta Neurochir (Wien) 2013;155:345-53.

2012 53.

54.

55.

Viersen VA, Greuters S, Korfage A, Van der Rijst C, Van Bochove V, Nanayakkara PW, Vandewalle E, Boer C. Hyperfibrinolysis in out of hospital cardiac arrest is associated with markers of hypoperfusion. Resuscitation 2012;83:1451-1455. Atasever B, Van der Kuil M, Boer C, Vonk AB, Schwarte LA, Girbes AR, Ince C, Beishuizen A, Groeneveld AB. Red blood cell transfusion compared with gelatin solution and no infusion: effect on microvascular perfusion, vascular density and oxygenation after cardiac surgery. Transfusion 2012;52:2452–2458. Dieleman JM, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, Schepp RM, Boer C, Moons KG, van Herwerden LA, Tijssen JG, Numan SC, Kalkman CJ, van Dijk D; for the Dexamethasone for Cardiac Surgery (DECS) Study Group. Intraoperative High-Dose Dexamethasone for Cardiac Surgery: A Randomized Controlled Trial. JAMA 2012;308:1761-1767.

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56.

57.

58.

59. 60.

61. 62.

63. 64.

65.

66.

67.

68.

Franschman G, Greuters S, Jansen WH, Posthuma LM, Peerdeman SM, Wattjes MP, Loer SA, Boer C. Hemostatic and cranial computed tomography characteristics in patients with acute and delayed coagulopathy after isolated traumatic brain injury. Brain Injury 2012;26:1464-1471. Vonk AB, Muntajit W, Bhagirath P, Van Barneveld LJ, Romijn JW, De Vroege R, Boer C. Residual blood processing by centrifugation, cell salvage or ultrafiltration in cardiac surgery: effects on clinical hemostatic and ex vivo rheological parameters. Blood Coagul Fibrinolysis 2012;23:622-628. Franschman G, Verburg N, Brens-Heldens V, Andriessen TMJC, Van der Naalt J, Peerdeman SM, Valk JP, Hoogerwerf N, Greuters S, Schober P, Vos PE, Christiaans HMT, Boer C. Effects of physician-based emergency medical service dispatch in severe traumatic brain injury on prehospital run time. Injury 2012;43:1838-1842. Boer C, Franschman G, Loer SA. Prehospital management of severe traumatic brain injury: concepts and ongoing controversies. Curr Opin Anesth 2012;25:556-562. Garnier RP, Van der Spoel AG, Sibarani-Ponsens R, Markhorst DG, Boer C. Level of agreement between Nexfin non-invasive arterial blood pressure with invasive arterial blood pressure measurements in children. BJA 2012;109:609-615. Bouwman RA, Boer C. Minimal invasive cardiac output monitoring: Get the dose of fluid right. BJA 2012;109:299-302. Van den Brom CE, Bulte CS, Kloeze M, Loer SA, Boer C, Bouwman RA. High-fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study. Cardiovasc Diabet 2012;11:74. Stoecklein K. Eekhof EW, Loer SA, Boer C. Does insulin and not reduced blood glucose levels decrease postoperative infections? EJA 2012;29:401-402. Koning NJ, Vonk AB, Van Barneveld, LJ, Beishuizen A, Atasever B, Van den Brom CE, Boer C. Pulsatile flow during cardiopulmonary bypass preserves postoperative microcirculatory perfusion irrespective of systemic hemodynamics. J Appl Physiol 2012;112:1727-1734. Van der Spoel AG, Voogel AJ, Folkers A, Boer C, Bouwman RA. Comparison of noninvasive continuous arterial waveform analysis (Nexfin) with transthoracic Doppler echocardiography for monitoring of cardiac output. J Clin Anesth 2012;24:304-309. Bulte CE, Slikkerveer J, Meijer RL, Gort D, Kamp O, Loer SA, de Marchi SF, Vogel R, Boer C, Bouwman RA. Contrast-enhanced ultrasound for myocardial perfusion imaging. Anesthesia Analgesia 2012;114:938-45. Bossers SM, Peerdeman SM, Oedayrajsingh Varma P, Baayen JC, de Witt Hamer PC, Schauer A, Loer SA, Boer C. Increases in cerebral metabolites during induction of propofol anaesthesia. BJA 2012;108:165-167. Franschman G, Boer C, Andriessen TMJC, Van der Naalt J, Horn J, Haitsma I, Jacobs B, Vos PE. Multicenter evaluation of the course of coagulopathy in patients with isolated traumatic brain injury: relation to CT characteristics and outcome. J Neurotrauma 2012;29:128-136.

2011 69.

70.

71. 72.

73. 74.

Atasever B, Boer C, Speekenbrink R, Seyffert J, Goedhart P, de Mol B, Ince C. Cardiac displacement during off-pump coronary artery bypass grafting surgery: effect on sublingual microcirculation and cerebral oxygenation. Interact CardioVasc Thorac Surg 2011;13:573-578. Sipkens LM, Treskes K, Ariese-Beldman K, Veerman DP, Boer C. Application of Nexfin HD noninvasive beat-to-beat arterial blood pressure monitoring in autonomic function testing. Blood Pressure Monitoring 2011; 16:246-251. Koning NJ, Atasever B, Vonk AB, Boer C. The effects of pulsatile cardiopulmonary bypass on microcirculatory perfusion: perspectives from a null-result study. J Cardiothorac Vasc Surg 2011; 25:e24. Greuters S, Van den Berg A, Franschman G, Viersen VA, Beishuizen A, Peerdeman SM, Boer C. Acute and delayed mild coagulopathy are related to outcome in patients with isolated traumatic brain injury. Crit Care 2011;15:R2. Geersing PG, Bulte CS, Viersen VA, Stek ML, Bouwman RA, Boer C, Loer SA. Beat-to-beat hemodynamic monitoring during electroconvulsive therapy. J ECT 2011;27:189-191. Keet SW, Bulte CS, Boer C, Bouwman RA. Reproducibility of Non-Standardized Autonomic Function Testing in the Preoperative Assessment Screening Clinic. Anaesthesia 2011;66:10-14.

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75.

76. 77. 78. 79.

80.

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Franschman G, Peerdeman SM, Andriessen TM, Greuters S, Toor EJ, Vos PE, Bakker FC, Loer SA, Boer C. The ALARM-TBI investigators. Effect of secondary prehospital risk factors on outcome in severe traumatic brain injury in the context of fast access to trauma care. J Trauma 2011;71:826-832. Bulte CS, Keet SW, Boer C, Bouwman RA. Level of agreement between heart rate variability and pulse rate variability in healthy subjects. Eur J Anaesth 2011;28:34-38. Mackie DP, Van Dehn F, Knape P, Breederveld RS, Boer C. Increase in Early Mechanical Ventilation of Burn Patients: an Effect of Current Emergency Trauma Management? J Trauma 2011;70:611-615. Koetsier E, Boer C, Loer SA. Complaints and incident reports related to anesthesia service are foremost attributed to non-technical skills. Eur J Anaesth 2011;28:29-33. Vonk AB, Meesters MI, Schats J, Romijn JW, Jansen EK, Boer C. Removal of low-dose aprotinin from combined aprotinin/tranexamic acid antifibrinolytic therapy increases transfusion requirements in cardiothoracic surgery. ICVTS 2011;12:135-139. Atasever B, Boer C, van der Kuil M, Lust E, Beishuizen A, Speekenbrink R, Seyffert J, de Mol B, Ince C. Quantitative imaging of microcirculatory response during nitroglycerin-induced hypotension. J Cardiothorac Vasc Anesth 2011;25:140-4. Appelman MH, Van Barneveld LJ, Romijn JW, Vonk AB, Boer C. The impact of balanced hydroxylethyl starch cardiopulmonary bypass priming solution on the fibrin part of clot formation: ex vivo rotation thromboelastometry. Perfusion 2011;25:175-180. Atasever B, Boer C, Goedhart P, Biervliet J, Seyffert J, Schwarte LA, Speekenbrink R, De Mol B, Ince C. Distinct alterations in sublingual microcirculatory blood flow and hemoglobin oxygenation in onpump and off-pump coronary artery bypass graft surgery. J Cardiothoracic Vasc Anesth 2011;25:784-90.

2010 83.

84.

85.

Van den Brom CE, Bosmans JW, Vlasblom R, Handoko ML, Huisman MC, Lubberink M, Molthoff CF, Lammertsma AA, Ouwens DM, Diamant M, Boer C. Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle. Cardiovascular Diabetology 2010;9:25. Franschman G, Greuters S, Loer SA, Boer C. The ALARM-TBI investigators. Prehospital treatment guidelines in severe traumatic brain injury: what really happens outside the hospital? Resuscitation 2010;81:261. Brinkman ACM, Romijn JWA, Barneveld LJM, Greuters S, Veerhoek D, Vonk ABA, Boer C. Profound effects of cardiopulmonary bypass priming solutions on the fibrin part of clot formation: an ex vivo evaluation using rotation thromboelastometry. J Cardiothoracic Vasc Anesth 2010;24:422-426.

2009 86.

87. 88.

89.

90. 91.

Handoko ML, Lamberts RR, Redout EM, de Man FS, Boer C, Simonides WS, Paulus WJ, Westerhof N, Allaart CP, Vonk Noordegraaf A. Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart. Am J Physiol Heart Circ Physiol 2009;297:H1752-9. Mackie DP, Spoelder EJ, Paauw RJ, Knape P, Boer C. Mechanical ventilation and fluid retention in burn patients. J Trauma 2009;67:1233-38. Van den Brom CE, Huisman MC, Vlasblom R, Boontje NM, Duijst S, Lubberink M, Molthoff CF, Lammertsma AA, Van der Velden J, Boer C, Ouwens DM, Diamant M. Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. Cardiovascular Diabetology 2009;8:39. Franschman G, Peerdeman SM, Greuters S, Vieveen J, Brinkman ACM, Christiaans HMT, Toor EJ, Jukema GN, Loer SA, Boer C. The ALARM-TBI investigators. Prehospital endotracheal intubation in patients with severe traumatic brain injury: guidelines versus reality. Resuscitation 2009;80:1147-51. Kamminga SK, Boer C, Paul MA, Vonk Noordegraaf A, Strack van Schijndel RJ. Occult pleural cryptococcosis in an immunocompromised patient. Intensive Care Med 2009;35:961-2. Greuters S, Christiaans HMT, Veenings B, Loer SA, Boer C. Evaluation of repatriation parameters: does medical history matter? J Trav Med 2009;16:1-6.

2008

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92. 93.

94.

Schober P, Meuleman EJ, Boer C, Loer SA, Schwarte LA. TURP syndrome detected and managed using transesophageal Doppler. Anaesth Analg 2008;107:921-925. Meischl C, Buermans H, Hazes T, Zuidwijk M, Musters RJ, Boer C, van Lingen A, Simonides WS, Blankenstein M, Dupuy C, Paulus W, Hack CE, Ris-Stalpers C, Roos D, Niessen HW. H9c2 cardiomyoblasts produce thyroid hormone. Am J Physiol Cell Physiol 2008;294:C1227-1233. Schober P, Schwarte LA, Boer C, Loer SA. Fatal outcome of Munchausen's syndrome. Resuscitation 2008;78:99-100.

BEFORE 2007 95.

96. 97.

98.

99. 100.

101.

102.

103.

104.

105.

106.

107.

108.

109.

Bouwman RA, Musters RJ, van Beek-Harmsen BJ, de Lange JJ, Lamberts RR, Loer SA, Boer C. Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species. Br J Anaesth 2007;99:639-45 Klaassen FA, Schober P, Schwarte LA, Boer C, Loer SA. Acute respiratory failure leading to emergency intubation: an unusual manifestation of Munchausen's syndrome. Resuscitation 2007;75:534-539. Ouwens DM, Diamant M, Fodor M, Habets DD, Pelsers MM, El Hasnaoui M, Dang ZC, van den Brom CE, Vlasblom R, Rietdijk A, Boer C, Coort SL, Glatz JF, Luiken JJ. Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia 2007;50:1938-1948. Redout EM, Wagner MJ, Zuidwijk MJ, Boer C, Musters RJ, van Hardeveld C, Paulus WJ, Simonides WS. Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. Cardiovasc Res 2007;75:770-781. Westerhof N, Boer C, Lamberts RR, Sipkema P. Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev 2006;86:1263-108. Bouwman RA, van't Hof FN, de Ruijter W, van Beek-Harmsen BJ, Musters RJ, de Lange JJ, Boer C. The mechanism of sevoflurane-induced cardioprotection is independent of the applied ischaemic stimulus in rat trabeculae. Br J Anaesth 2006;97:307-314. Bouwman RA, Salic K, Padding FG, Eringa EC, van Beek-Harmsen BJ, Matsuda T, Baba A, Musters RJ, Paulus WJ, de Lange JJ, Boer C. Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger. Circulation 2006;114:I226-232. Kim YK, Suarez J, Hu Y, McDonough PM, Boer C, Dix DJ, Dillmann WH. Deletion of the inducible 70kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy. Circulation 2006;113:2589-2597. Simůnek T, Boer C, Bouwman RA, Vlasblom R, Versteilen AM, Sterba M, Gersl V, Hrdina R, Ponka P, de Lange JJ, Paulus WJ, Musters RJ. SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death. J Mol Cell Cardiol 2005;39:345-354. Boer C, Groeneveld AB, Scheffer GJ, de Lange JJ, Westerhof N, Sipkema P. Induced nitric oxide impairs relaxation but not contraction in endotoxin-exposed rat pulmonary arteries. J Surg Res 2005;127:197-202. Ouwens DM, Boer C, Fodor M, de Galan P, Heine RJ, Maassen JA, Diamant M. Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats. Diabetologia 2005;48:1229-1237. Bouwman RA, Musters RJ, van Beek-Harmsen BJ, de Lange JJ, Boer C. Reactive oxygen species precede protein kinase C-delta activation independent of adenosine triphosphate-sensitive mitochondrial channel opening in sevoflurane-induced cardioprotection. Anesthesiology 2004;100:506-514. de Ruijter W, Musters RJ, Boer C, Stienen GJ, Simonides WS, de Lange JJ. The cardioprotective effect of sevoflurane depends on protein kinase C activation, opening of mitochondrial K(+)(ATP) channels, and the production of reactive oxygen species. Anesth Analg 2003;97:1370-1376. Boer C, Van Nieuw Amerongen GP, Groeneveld AJ, Scheffer GJ, De Lange JJ, Westerhof N, Van Hinsbergh VW, Sipkema P. Smooth muscle F-actin disassembly and RhoA/Rho kinase signaling during endotoxin-induced alterations in pulmonary arterial compliance. Am J Physiol Lung Cell Mol Physiol 2004; 287:L649-655. Bolz S-S, Vogel L, Sollinger D, Derwand R, Boer C, Pitson SM, Spiegel S, Pohl U. Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase. Circulation 2003; 108:342-347.

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110. 111.

112. 113. 114.

Marques KM, Spruijt HJ, Boer C, Westerhof N, Visser CA, Visser FC. The diastolic flow-pressure gradient relation in coronary stenoses in humans. J Am Coll Cardiol 2002;39:1630-1636. Boer C, van der Linden PJ, Scheffer GJ, Westerhof N, de Lange JJ, Sipkema P. RhoA/Rho kinase and nitric oxide modulate the agonist-induced pulmonary artery diameter response time. Am J Physiol Heart Circ Physiol 2002;282:H990-998. Piepot HA, Boer C, Groeneveld AB, Van Lambalgen AA, Sipkema P. Lipopolysaccharide impairs endothelial nitric oxide synthesis in rat renal arteries. Kidney Int 2000;57:2502-2510. Boer C, Scheffer GJ, de Lange JJ, Westerhof N, Sipkema P. Alpha-1-adrenoceptor stimulation induces nitric oxide release in rat pulmonary arteries. J Vasc Res 1999;36:79-81. Boer C, Treebus AN, Zuurmond WW, de Lange JJ. Compliance in administration of prescribed analgesics. Anaesthesia 1997;52:1177-1181.

BOOK CHAPTERS Boer C. Perioperatieve Monitoring of Tissue Perfusion: New Developments. Annual Update in Intensive Care and Emergency Medicine. J.-L. Vincent (editor). Springer-Verlag Berlin Heidelberg 2013:291-300.

NATIONAL PEER-REVIEWED PUBLICATIONS 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

Bulte CSE, Loer SA, Boer C, Bouwman RA. The impact of general anesthesia on myocardial perfusion and microvascular responses. Neth J Anesth 2015;3:86-93. Boer C. The PROPPR transfusion ratio in severe traumatic haemorrhage. Neth J Critical Care 2015. Boer C, Eikenboom HC, Romijn JW, Hendriks HG, Van Pampus L. Platform Perioperatieve Hemostase. Tijdschr v Bloedtransfusie 2012. Ariese K, Brans TA, van den Elsen MJ, Loer SA, Boer C. Acute Porphyria Pandora’s box in perioperative care. Neth J Anesth 2011;3:20-30. Eickhoff C, Hering JP, Gabel LF, Boer C, Borjesson PK. Post-spinal anesthesia-induced hearing loss: is there a need for increased patient awareness? Neth J Anesth 2010;5:20-21. Greuters S, van den Berg A, van der Rijst CMJ, Viersen V, Schwarte LA, Boer C. Secondary bleeding in traumatic brain injury: a case report. Neth J Anesth 2010;1:18-22. Romijn JWA, Greuters S, Vonk ABA, Loer SA, Boer C. Perioperatief gebruik van fibrinogeen concentraat voor de behandeling van coagulopathie. Neth J Anesth 2010;1:11-17. Coumou JF, Thurkow AL, Boer C, Van den Elsen MJ, Brans TA. Venous air-embolism in operative hysteroscopy. Neth J Anesth 2009;21:29-32. Bouwman RA, Musters RJP, Lange de JJ, Boer C. Volatile anaesthetics and the heart. Neth J Crit Care 2006;5:547-553. Boer C, Scheffer GJ. Nitric Oxide Inhalation. Neth J Crit Care 1999;13:21-23.

OTHER PUBLICATIONS 1. 2. 3. 4.

Boer C. Rotatie thromboelastometrie. A&I 2013. Keet SW, Bulte CS, Garnier RP, Boer C, Bouwman RA. Reference values for short-term heart rate variability in healthy adults. Anaesthesia E-letter 2013. Nuijten M, Mittendorf T, Boer C. A Few Practical Issues for the Conduction of a Budget Impact Analysis (BIA). ISPOR connections 2010. Spoelder EJ, Bleeker CP, Boer C. Prehospitale endotracheale intubatie in de militaire setting: Een kritische beschouwing vanuit anesthesiologisch perspectief. Ned Mil Geneesk Tijdschr 2010;4.

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